HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-1-[4-(Trifluoromethyl)phenyl]ethylamine → N-{(1R)-1-[4-(trifluoromethyl)phenyl]ethyl}-N-[4-(3-undecyl-1,2,4-oxadiazol-5-yl)benzyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-1-[4-(Trifluoromethyl)phenyl]ethylamine | HCID 821259 | — |
| Reactant | 4-(3-Undecyl-1,2,4-oxadiazol-5-yl)benzaldehyde | HCID 86598531 | — |
| Product | N-{(1R)-1-[4-(trifluoromethyl)phenyl]ethyl}-N-[4-(3-undecyl-1,2,4-oxadiazol-5-yl)benzyl]amine | HCID 67187997 | 71% |
Reaction Steps
The same procedure as employed in the preparation of Example 226 (step a) but using 4-(3-undecyl-1,2,4-oxadiazol-5-yl)benzaldehyde and (1R)-1-[4-(trifluoromethyl)phenyl]ethylamine gave the title compound as a colorless oil (71%). M+(LC/MS(ESI)): 502.4. HPLC (Condition A), Rt: 5.04 min (HPLC purity: 99.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592477B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-fff9dacc9abe4e9f9bd62e984d3430ab |
| Source note | uspto-grants-2009_09 |