(1S)-1-[4-(Trifluoromethyl)phenyl]ethan-1-amine → HCID 67187817, compound

HRID 735905Notes

Reaction equation

HRID 735905 reaction equation
[CH:1]([C:3]1[CH:18]=[CH:17][C:6]([C:7]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:8])=[CH:5][CH:4]=1)=O.[F:19][C:20]([F:31])([F:30])[C:21]1[CH:26]=[CH:25][C:24]([C@@H:27]([NH2:29])[CH3:28])=[CH:23][CH:22]=1>>[F:19][C:20]([F:30])([F:31])[C:21]1[CH:22]=[CH:23][C:24]([C@@H:27]([NH:29][CH2:1][C:3]2[CH:18]=[CH:17][C:6]([C:7]([O:9][CH2:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[O:8])=[CH:5][CH:4]=2)[CH3:28])=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 2779052(1S)-1-[4-(Trifluoromethyl)phenyl]ethan-1-amineHCID 11528845Benzyl 4-formylbenzoate

Product 1

HCID 67187817HCID 67187817, compoundYield 83%

Procedure

The same procedure as employed in the preparation of Example 226 (step a) but using benzyl 4-formylbenzoate and (1S)-1-[4-(trifluoromethyl)phenyl]ethylamine gave the title compound as a pale yellow oil (83%). M+(LC/MS(ESI)): 414.3. HPLC (Condition A), Rt: 3.77 min (HPLC purity: 99.1%).

Workup

  1. customThe same procedure as employed in the preparation of Example 226 (step a) but

Sources & evidence

ORD record
ord-1c9a1a790907498685ef3ef83e25445a
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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