HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S)-1-[4-(Trifluoromethyl)phenyl]ethylamine → benzyl 4-[({(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}amino)methyl]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S)-1-[4-(Trifluoromethyl)phenyl]ethylamine | HCID 2779052 | — |
| Reactant | Benzyl 4-formylbenzoate | HCID 11528845 | — |
| Product | benzyl 4-[({(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}amino)methyl]benzoate | HCID 67187817 | 83% |
Reaction Steps
The same procedure as employed in the preparation of Example 226 (step a) but using benzyl 4-formylbenzoate and (1S)-1-[4-(trifluoromethyl)phenyl]ethylamine gave the title compound as a pale yellow oil (83%). M+(LC/MS(ESI)): 414.3. HPLC (Condition A), Rt: 3.77 min (HPLC purity: 99.1%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592477B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-1c9a1a790907498685ef3ef83e25445a |
| Source note | uspto-grants-2009_09 |