HCID 10288817, compound → HCID 69004626, compound

HRID 735937Notes

Reaction equation

HRID 735937 reaction equation
[O:1]=[C:2]([N:6]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]#[C:26][C:27]2[CH:32]=[CH:31][C:30]([CH2:33][CH2:34][CH3:35])=[CH:29][CH:28]=2)=[CH:21][CH:20]=1)[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=1)[C:3]([OH:5])=[O:4]>CCOC(C)=O>[O:1]=[C:2]([N:6]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([CH2:33][CH2:34][CH3:35])=[CH:29][CH:28]=2)=[CH:21][CH:20]=1)[CH2:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]([F:15])([F:16])[F:17])=[CH:12][CH:13]=1)[C:3]([OH:5])=[O:4]

Participants

3

Reactant 1

HCID 10288817HCID 10288817, compound

Product 1

HCID 69004626HCID 69004626, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The same procedure as employed in the preparation of Example 1 (step c) but using oxo{{4-[(4-propylphenyl)ethynyl]benzyl}[4-(trifluoromethyl)benzyl]amino}acetic acid in EtOAc gave the title compound as a colorless oil (51%). M−(LC/MS(ESI)): 482. HPLC (Condition A), Rt: 5.43 min (HPLC purity: 89.2%).

Workup

  1. customThe same procedure as employed in the preparation of Example 1 (step c)

Sources & evidence

ORD record
ord-04c1881c6fc3475190ae599ffd49269d
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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