1-Ethynyl-4-propylbenzene → Ethyloxo{({3-[(4-propylphenyl)ethynyl]-1-benzofuran-5-yl}methyl)[4 (trifluoromethyl)benzyl]amino}acetate

Participants

Reaction Steps

The same procedure as employed in the preparation of Example 226 (step c) but using ethyl{[(3-bromo-1-benzofuran-5-yl)methyl][4-(trifluoromethyl)benzyl]amino}(oxo)acetate and 1-ethynyl-4-propylbenzene under microwave conditions (300 W, 120° C., 10 min) gave the title compound as a yellow oil (5%). M−(LC/MS(ESI)): 545.8; M+(LC/MS(ESI)): 548.2 HPLC (Condition A), Rt: 5.85 min (HPLC purity: 92.4%).

Provenance & Evidence