5-Tetralinylamine → HCID 67186807, compound

HRID 735962Notes

Reaction equation

[CH2:1]([C:9]1[N:13]=[C:12]([C:14]2[CH:21]=[CH:20][C:17]([CH:18]=O)=[CH:16][CH:15]=2)[O:11][N:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[C:22]1([NH2:32])[C:31]2[CH2:30][CH2:29][CH2:28][CH2:27][C:26]=2[CH:25]=[CH:24][CH:23]=1>>[C:22]1([NH:32][CH2:18][C:17]2[CH:20]=[CH:21][C:14]([C:12]3[O:11][N:10]=[C:9]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[N:13]=3)=[CH:15][CH:16]=2)[C:31]2[CH2:30][CH2:29][CH2:28][CH2:27][C:26]=2[CH:25]=[CH:24][CH:23]=1

Participants

Reactant 2

HCID 166715-Tetralinylamine

HCID 865985324-(3-Octyl-1,2,4-oxadiazol-5-yl)benzaldehyde

Product 1

HCID 67186807HCID 67186807, compound

Procedure

The same procedure as employed in the preparation of Example 357 (step a) but using 4-(3-octyl-1,2,4-oxadiazol-5-yl)benzaldehyde and 5,6,7,8-tetrahydronaphthalen-1-ylamine gave the title compound as an oil. M+(LC/MS(ESI)): 418.4. HPLC (Condition A), Rt: 5.83 min (HPLC purity: 82.3%).

Workup

customThe same procedure as employed in the preparation of Example 357 (step a) but

Sources & evidence

ORD record: ord-d7857bc82d274300a4bafb585464802c
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07592477B2

Reaction notes

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