3-(Trifluoromethyl)benzylamine → N-[3-(trifluoromethyl)benzyl]-N-[3-(3-undecyl-1,2,4-oxadiazol-5-yl)benzyl]amine

HRID 735973Notes

Reaction equation

HRID 735973 reaction equation
[CH2:1]([C:12]1[N:16]=[C:15]([C:17]2[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=2)[CH:20]=O)[O:14][N:13]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[F:25][C:26]([F:36])([F:35])[C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH2:30][NH2:31]>>[F:25][C:26]([F:35])([F:36])[C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH2:30][NH:31][CH2:20][C:19]1[CH:22]=[CH:23][CH:24]=[C:17]([C:15]2[O:14][N:13]=[C:12]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[N:16]=2)[CH:18]=1

Participants

3

Reactant 2

HCID 759623-(Trifluoromethyl)benzylamineHCID 865985383-(3-Undecyl-1,2,4-oxadiazol-5-yl)benzaldehyde

Product 1

HCID 67187099N-[3-(trifluoromethyl)benzyl]-N-[3-(3-undecyl-1,2,4-oxadiazol-5-yl)benzyl]amine

Procedure

The same procedure as employed in the preparation of Example 357 (step a) but using 3-(3-undecyl-1,2,4-oxadiazol-5-yl)benzaldehyde and 3-(trifluoromethyl)benzylamine gave the title compound as an oil. M+(LC/MS(ESI)): 488.5. HPLC (Condition A), Rt: 4.86 min (HPLC purity: 66.8%).

Workup

  1. customThe same procedure as employed in the preparation of Example 357 (step a) but

Sources & evidence

ORD record
ord-db3438f35f77467e9d412181579a60fa
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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