4-((Trifluoromethyl)sulfonyl)benzylamine hydrochloride → N-{4-[(trifluoromethyl)sulfonyl]benzyl}-N-[3-(3-undecyl-1,2,4-oxadiazol-5-yl)benzyl]amine

HRID 735979Notes

Reaction equation

HRID 735979 reaction equation
[CH2:1]([C:12]1[N:16]=[C:15]([C:17]2[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=2)[CH:20]=O)[O:14][N:13]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].Cl.[F:26][C:27]([F:40])([F:39])[S:28]([C:31]1[CH:38]=[CH:37][C:34]([CH2:35][NH2:36])=[CH:33][CH:32]=1)(=[O:30])=[O:29]>>[F:39][C:27]([F:26])([F:40])[S:28]([C:31]1[CH:38]=[CH:37][C:34]([CH2:35][NH:36][CH2:20][C:19]2[CH:22]=[CH:23][CH:24]=[C:17]([C:15]3[O:14][N:13]=[C:12]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[N:16]=3)[CH:18]=2)=[CH:33][CH:32]=1)(=[O:29])=[O:30]

Participants

3

Reactant 2

HCID 671882734-((Trifluoromethyl)sulfonyl)benzylamine hydrochlorideHCID 865985383-(3-Undecyl-1,2,4-oxadiazol-5-yl)benzaldehyde

Product 1

HCID 67187372N-{4-[(trifluoromethyl)sulfonyl]benzyl}-N-[3-(3-undecyl-1,2,4-oxadiazol-5-yl)benzyl]amine

Procedure

The same procedure as employed in the preparation of Example 357 (step a) but using 3-(3-undecyl-1,2,4-oxadiazol-5-yl)benzaldehyde and 4-[(trifluoromethyl)sulfonyl]benzylamine hydrochloride gave the title compound as an oil. M+(LC/MS(ESI)): 552.5. HPLC (Condition A), Rt: 4.85 min (HPLC purity: 62.0%).

Workup

  1. customThe same procedure as employed in the preparation of Example 357 (step a) but

Sources & evidence

ORD record
ord-54e7d93f6fe8481fb72ae4490b396842
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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