2-(2-Fluorophenyl)ethylamine → N-(4-dodec-1-ynylbenzyl)-N-[2-(2-fluorophenyl)ethyl]amine

HRID 735992Notes

Reaction equation

HRID 735992 reaction equation
[C:1]([C:13]1[CH:20]=[CH:19][C:16]([CH:17]=O)=[CH:15][CH:14]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[CH2:28][CH2:29][NH2:30]>>[C:1]([C:13]1[CH:20]=[CH:19][C:16]([CH2:17][NH:30][CH2:29][CH2:28][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[F:21])=[CH:15][CH:14]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 6433572-(2-Fluorophenyl)ethylamineHCID 865985364-Dodec-1-ynylbenzaldehyde

Product 1

HCID 67187042N-(4-dodec-1-ynylbenzyl)-N-[2-(2-fluorophenyl)ethyl]amine

Procedure

The same procedure as employed in the preparation of Example 394 (step b) but using 4-dodec-1-ynylbenzaldehyde and 2-(2-fluorophenyl)ethylamine gave the title compound as an oil. M+(LC/MS(ESI)): 394.4. HPLC (Condition A), Rt: 5.00 min (HPLC purity: 93.6%).

Workup

  1. customThe same procedure as employed in the preparation of Example 394 (step b)

Sources & evidence

ORD record
ord-b8c52715351c4a4995ed7a069fc7149e
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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