2-(Trifluoromethyl)benzylamine → HCID 67186742, compound

HRID 735995Notes

Reaction equation

HRID 735995 reaction equation
[C:1]([C:11]1[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[F:19][C:20]([F:30])([F:29])[C:21]1[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23][NH2:24]>>[C:1]([C:11]1[CH:18]=[CH:17][C:14]([CH2:15][NH:24][CH2:23][C:22]2[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=2[C:20]([F:19])([F:29])[F:30])=[CH:13][CH:12]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

Participants

3

Reactant 2

HCID 764472-(Trifluoromethyl)benzylamineHCID 578413204-Dec-1-ynylbenzaldehyde

Product 1

HCID 67186742HCID 67186742, compound

Procedure

The same procedure as employed in the preparation of Example 394 (step b) but using 4-dec-1-ynylbenzaldehyde and 2-(trifluoromethyl)benzylamine gave the title compound as an oil. M+(LC/MS(ESI)): 402.3. HPLC (Condition A), Rt: 4.71 min (HPLC purity: 86.5%).

Workup

  1. customThe same procedure as employed in the preparation of Example 394 (step b)

Sources & evidence

ORD record
ord-8019d8244b5d45c0bbed163aa6bb5988
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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