2-(Trifluoromethyl)benzylamine → N-(4-dodec-1-ynylbenzyl)-N-[2-(trifluoromethyl)benzyl]amine

HRID 735996Notes

Reaction equation

HRID 735996 reaction equation
[C:1]([C:13]1[CH:20]=[CH:19][C:16]([CH:17]=O)=[CH:15][CH:14]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[F:21][C:22]([F:32])([F:31])[C:23]1[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=1[CH2:25][NH2:26]>>[C:1]([C:13]1[CH:20]=[CH:19][C:16]([CH2:17][NH:26][CH2:25][C:24]2[CH:27]=[CH:28][CH:29]=[CH:30][C:23]=2[C:22]([F:21])([F:31])[F:32])=[CH:15][CH:14]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 764472-(Trifluoromethyl)benzylamineHCID 865985364-Dodec-1-ynylbenzaldehyde

Product 1

HCID 67185985N-(4-dodec-1-ynylbenzyl)-N-[2-(trifluoromethyl)benzyl]amine

Procedure

The same procedure as employed in the preparation of Example 394 (step b) but using 4-dodec-1-ynylbenzaldehyde and 2-(trifluoromethyl)benzylamine gave the title compound as an oil. M+(LC/MS(ESI)): 430.4. HPLC (Condition A), Rt: 5.05 min (HPLC purity: 96.9%).

Workup

  1. customThe same procedure as employed in the preparation of Example 394 (step b)

Sources & evidence

ORD record
ord-36bd7ebffb064a16891cdcb79426cbfa
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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