Ammonium Hydroxide → Asp Asn succinimide

HRID 736017Notes

Reaction equation

[NH2:1][C@H:2]([C:7]([O-:9])=[O:8])[CH2:3][C:4]([O-:6])=[O:5].[NH2:10][C@H:11]([C:16]([OH:18])=[O:17])[CH2:12][C:13](=[O:15])[NH2:14].[NH4+].[OH-]>>[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4](=[O:5])[OH:6].[NH2:10][C@H:11]([C:16]([OH:18])=[O:17])[CH2:12][C:13](=[O:15])[NH2:14].[C:16]1(=[O:18])[NH:14][C:13](=[O:15])[CH2:12][CH2:11]1

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 86612007Aspartate asparagine

Product 1

HCID 69442862Asp Asn succinimide

Procedure

This copolymer can then be converted, if desired, to a low molecular weight aspartate/asparagine copolymer, by treating with aqueous NH4OH and drying the solution, preferably at about 60° C. Finally, a low molecular weight Asp/Asn/succinimide terpolymer can be produced by acidifying an aqueous solution of the aspartate/asparagine copolymer, e.g. to about pH 4, drying the solution, preferably at about 60° C.-80° C., and heating the residue at about 170-180° C. under vacuum or an inert atmosphere.

Workup

customdrying the solution
custompreferably at about 60° C

Sources & evidence

ORD record: ord-c8a77cbb3cb547159b65a1d8fca60604
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595007B2

Reaction notes

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