反应详情

To a methanolic solution of 4-Benzyl-2-(1,2-diphenyl-vinyl)-morpholine (4.9 g, 13.9 mmol) is added ammonium formate (14 g, 222.2 mmol) and 10% Pd—C (5 g). The reaction is stirred under nitrogen and heated at reflux for 30 min then cooled to room temperature and filtered through Celite®. The filtrate is concentrated under reduced pressure and the residue is taken up in methanol and purified by cationic ion exchange resin SCX-2® chromatography. The purified residue (2.9 g, 80%) comprises a 3:1 ratio of diastereoisomers.

1. temperatureheated
2. temperatureat reflux for 30 min
3. filtrationfiltered through Celite®
4. concentrationThe filtrate is concentrated under reduced pressure
5. custompurified by cationic ion exchange resin SCX-2® chromatography