反应详情

β-Benzyltryptamine was prepared by the addition of 2-1H-indol-3-yl-3-phenylacrylonitrile (500 mg, 2.04 mmol) and EtOH (25 mL) to a N2 purged 100 mL flask. To the solution was added approximately 2 g of Raney-Ni slurry. To the reaction solution, dropwise with stirring, was added hydrazine monohydrate (2.5 mL). The reaction solution was allowed to stir at 65° C. for 4 hours. The slurry was filtered through a pad of Celite to remove excess Raney-Ni. The filtrate was concentrated under reduced pressure, and the crude product was used without further purification; MS (ESI): 251 (MH+).

1. custompurged 100 mL flask
2. additionTo the solution was added approximately 2 g of Raney-Ni slurry
3. additionwas added hydrazine monohydrate (2.5 mL)
4. stirringto stir at 65° C. for 4 hours
5. filtrationThe slurry was filtered through a pad of Celite
6. customto remove excess Raney-Ni
7. concentrationThe filtrate was concentrated under reduced pressure
8. customthe crude product was used without further purification