Piperazine → HCID 59793748, compound

HRID 736124Notes

Reaction equation

HRID 736124 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>O>[F:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 8228653,4-Difluorobenzenesulfonamide

Product 1

HCID 59793748HCID 59793748, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 0.5 g (3 mmol) 3,4-Difluoro-benzenesulfonamide and 1.15 g (13 mmol) piperazine in 2.3 ml water was heated to 110° C. for 3 h and subsequently the precipitate was filtered off and washed with water and toluene. The residue was dried under high vacuum to yield 0.578 g (86%) of the title compound as white crystals.

Workup

  1. filtrationsubsequently the precipitate was filtered off
  2. washwashed with water and toluene
  3. customThe residue was dried under high vacuum

Sources & evidence

ORD record
ord-4f362aeba1e042bd98a06ce1bbdc9f1c
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

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