1-(3-Fluoro-4-piperazin-1-ylphenyl)ethanone → 3-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-bromo benzonitrile

HRID 736128Notes

Reaction equation

HRID 736128 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:14](=[O:16])[CH3:15])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.[Br:17][C:18]1[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[CH:23][C:19]=1[C:20](O)=[O:21]>>[C:14]([C:4]1[CH:5]=[CH:6][C:7]([N:8]2[CH2:13][CH2:12][N:11]([C:20]([C:19]3[CH:23]=[C:24]([CH:25]=[CH:26][C:18]=3[Br:17])[C:27]#[N:28])=[O:21])[CH2:10][CH2:9]2)=[C:2]([F:1])[CH:3]=1)(=[O:16])[CH3:15]

Participants

3

Reactant 2

HCID 6856101-(3-Fluoro-4-piperazin-1-ylphenyl)ethanoneHCID 532567612-Bromo-5-cyanobenzoic acid

Product 1

HCID 597935213-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-bromo benzonitrileYield 49%

Procedure

Title compound was prepared according to procedure described in example K/step 2 from 1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone and 2-bromo-5-cyano-benzoic acid, (49% yield, white solid, MS (m/e): 430 (M+, 100%).

Sources & evidence

ORD record
ord-6c71cbbd7e2d42c2acb470a4194b6a4c
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

Loading…