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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 736128Generated: October 27, 2026

1-(3-Fluoro-4-piperazin-1-ylphenyl)ethanone → 3-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-bromo benzonitrile

https://huagongshe.com/reaction/736128

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(3-Fluoro-4-piperazin-1-ylphenyl)ethanoneHCID 685610—
Reactant2-Bromo-5-cyanobenzoic acidHCID 53256761—
Product3-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-bromo benzonitrileHCID 5979352149%

Reaction Steps

Title compound was prepared according to procedure described in example K/step 2 from 1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone and 2-bromo-5-cyano-benzoic acid, (49% yield, white solid, MS (m/e): 430 (M+, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07595314B2
Source datasetuspto-grants-2009_09
ORD IDord-6c71cbbd7e2d42c2acb470a4194b6a4c
Source noteuspto-grants-2009_09