Iodoethane → 2-Chloro-5-(ethanesulfonyl)benzoic acid

HRID 736133Notes

Reaction equation

HRID 736133 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl[C:16]1C=CC(S(O)=O)=CC=1C(O)=O.C(I)C>C(O)C>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH2:14][CH3:16])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 23291322-Chloro-5-(methylsulphonyl)benzoic acidHCID 151129042-Chloro-5-sulfino-benzoic acid

Product 1

HCID 431409922-Chloro-5-(ethanesulfonyl)benzoic acidYield 27%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was synthesised according to the procedure described for the synthesis of 2-Chloro-5-methanesulfonyl-benzoic acid from 2-Chloro-5-sulfino-benzoic acid and ethyl iodide in 20 ml ethanol/20 ml water and obtained in 27% yield. MS (m/e): 247.1 (MH−, 100%).

Workup

  1. customobtained in 27% yield

Sources & evidence

ORD record
ord-2f0dd6f9f6ae4b71a1719801cebe281d
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

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