Ethylamine → 2-Chloro-5-(ethylsulfamoyl)benzoic acid

HRID 736138Notes

Reaction equation

HRID 736138 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11](=[O:15])(=[O:14])[NH:12][CH3:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl[C:17]1C=CC(S(O)=O)=CC=1C(O)=O.C(N)C>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11](=[O:15])(=[O:14])[NH:12][CH2:13][CH3:17])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

4

Reactant 3

HCID 6341EthylamineHCID 111724Benzoic acid, 2-chloro-5-[(methylamino)sulfonyl]-HCID 151129042-Chloro-5-sulfino-benzoic acid

Product 1

HCID 167683232-Chloro-5-(ethylsulfamoyl)benzoic acidYield 78%

Procedure

The title compound was synthesised according to the procedure described for 2-Chloro-5-methylsulfamoyl-benzoic acid from 2-Chloro-5-sulfino-benzoic acid and ethylamine and obtained in 78% yield. MS (m/e): 262.2 (MH−, 100%).

Workup

  1. customobtained in 78% yield

Sources & evidence

ORD record
ord-c1f91aa6c40c45dd80d4157aa6073ca8
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

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