2-Morpholin-4-yl-5-nitro-benzoyl chloride → [4-(2-Fluoro-4-methyl-phenyl)-piperazin-1-yl]-(2-morpholin-4-yl-5-nitro-phenyl)-methanone

HRID 736163Notes

Reaction equation

HRID 736163 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.[N:15]1([C:21]2[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][C:22]=2[C:23](Cl)=[O:24])[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:10][CH2:11][N:12]([C:23]([C:22]2[CH:26]=[C:27]([N+:30]([O-:32])=[O:31])[CH:28]=[CH:29][C:21]=2[N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[O:24])[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 172741532-Morpholin-4-yl-5-nitro-benzoyl chlorideHCID 213637771-(2-Fluoro-4-methylphenyl)piperazine

Product 1

HCID 59793739[4-(2-Fluoro-4-methyl-phenyl)-piperazin-1-yl]-(2-morpholin-4-yl-5-nitro-phenyl)-methanoneYield 70%

Procedure

Title compound was prepared according to procedure described in example 46 from 1-(2-Fluoro-4-methyl-phenyl)-piperazine and 2-morpholin-4-yl-5-nitro-benzoyl chloride (70% yield, yellow oil, MS (m/e): 429.2 (M+H+, 100%).

Sources & evidence

ORD record
ord-c50d5765684540b78f5a814efe886169
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

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