2-Morpholin-4-yl-5-nitro-benzoyl chloride → (4-(3-Fluoro-4-(trifluoromethyl)phenyl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

HRID 736180Notes

Reaction equation

HRID 736180 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH:5]=[CH:6][C:7]=1[C:8]([F:11])([F:10])[F:9].[N:18]1([C:24]2[CH:32]=[CH:31][C:30]([N+:33]([O-:35])=[O:34])=[CH:29][C:25]=2[C:26](Cl)=[O:27])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>>[F:1][C:2]1[CH:3]=[C:4]([N:12]2[CH2:17][CH2:16][N:15]([C:26]([C:25]3[CH:29]=[C:30]([N+:33]([O-:35])=[O:34])[CH:31]=[CH:32][C:24]=3[N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)=[O:27])[CH2:14][CH2:13]2)[CH:5]=[CH:6][C:7]=1[C:8]([F:9])([F:11])[F:10]

Participants

3

Reactant 2

HCID 172741532-Morpholin-4-yl-5-nitro-benzoyl chlorideHCID 597935951-(3-Fluoro-4-trifluoromethyl-phenyl)-piperazine

Product 1

HCID 44580341(4-(3-Fluoro-4-(trifluoromethyl)phenyl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

Procedure

The title compound was prepared according to the procedure described for example 46 from 1-(3-Fluoro-4-trifluoromethyl-phenyl)-piperazine and 2-Morpholin-4-yl-5-nitro-benzoyl chloride (62%, yellow solid, MS (m/e): 483.2 (M+H, 100%)

Sources & evidence

ORD record
ord-b8c30e4750164fc58510fb899fc302e5
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

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