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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 736180Generated: October 29, 2026

2-Morpholin-4-yl-5-nitro-benzoyl chloride → (4-(3-Fluoro-4-(trifluoromethyl)phenyl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

https://huagongshe.com/reaction/736180

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Morpholin-4-yl-5-nitro-benzoyl chlorideHCID 17274153—
Reactant1-(3-Fluoro-4-trifluoromethyl-phenyl)-piperazineHCID 59793595—
Product(4-(3-Fluoro-4-(trifluoromethyl)phenyl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanoneHCID 44580341—

Reaction Steps

The title compound was prepared according to the procedure described for example 46 from 1-(3-Fluoro-4-trifluoromethyl-phenyl)-piperazine and 2-Morpholin-4-yl-5-nitro-benzoyl chloride (62%, yellow solid, MS (m/e): 483.2 (M+H, 100%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07595314B2
Source datasetuspto-grants-2009_09
ORD IDord-b8c30e4750164fc58510fb899fc302e5
Source noteuspto-grants-2009_09