Piperidine → 5-Methanesulfonyl-2-piperidin-1-yl-benzoic acid

HRID 736212Notes

Reaction equation

HRID 736212 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3].Cl[C:20]1C=CC(S(C)(=O)=O)=CC=1C(O)=O.N1CCCCC1>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:20]2)=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:3])=[O:4]

Participants

4

Reactant 3

HCID 8082PiperidineHCID 23291322-Chloro-5-(methylsulphonyl)benzoic acidHCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

Product 1

HCID 218061575-Methanesulfonyl-2-piperidin-1-yl-benzoic acidYield 78%

Procedure

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid (Example Y) from 2-Chloro-5-methanesulfonyl-benzoic acid and piperidine and obtained in 78% yield. MS (m/e): 282.0 (M−H+100%)

Workup

  1. customobtained in 78% yield

Sources & evidence

ORD record
ord-7b31a2b9369c42f4ae33335e69334e33
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

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