Piperidine → HCID 21806156, compound

HRID 736215Notes

Reaction equation

HRID 736215 reaction equation
CS(C1C=C[C:8]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=C(C=1)C(O)=O)(=O)=O.Cl[C:20]1[CH:28]=[CH:27][C:26]([S:29](=[O:33])(=[O:32])[NH:30][CH3:31])=[CH:25][C:21]=1[C:22]([OH:24])=[O:23].N1CCCCC1>>[CH3:31][NH:30][S:29]([C:26]1[CH:27]=[CH:28][C:20]([N:14]2[CH2:8][CH2:15][CH2:16][CH2:17][CH2:18]2)=[C:21]([CH:25]=1)[C:22]([OH:24])=[O:23])(=[O:33])=[O:32]

Participants

4

Reactant 3

HCID 8082PiperidineHCID 111724Benzoic acid, 2-chloro-5-[(methylamino)sulfonyl]-HCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

Product 1

HCID 21806156HCID 21806156, compoundYield 48%

Procedure

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid (Example S) from 2-Chloro-5-methylsulfamoyl-benzoic acid and piperidine and obtained in 48% yield. MS (m/e): 297.4 MH−(100%).

Workup

  1. customobtained in 48% yield

Sources & evidence

ORD record
ord-c77f1d44f5064a87b1f0cd7c94797db9
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

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