Trifluoroacetic acid → 2,3-Difluoro-4-piperazin-1-yl-benzonitrile trifluoro-acetic acid

HRID 736225Notes

Reaction equation

HRID 736225 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]#[N:21])=[C:16]([F:22])[C:15]=2[F:23])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>ClCCl>[F:22][C:16]1[C:15]([F:23])=[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:19]=[CH:18][C:17]=1[C:20]#[N:21].[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 688407454-(4-Cyano-2,3-difluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 688402612,3-Difluoro-4-piperazin-1-yl-benzonitrile trifluoro-acetic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-(4-Cyano-2,3-difluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (0.72 g) in dichloromethane (5 mL) was added trifluoroacetic acid and the reaction mixture was stirred at room temperature for 30 minutes. After such time the reaction mixture was concentrated in vacuo to yield the title compound (0.63 g). MS (m/e): 224.3 (M+H+, 100%).

Workup

  1. concentrationAfter such time the reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-1048635814874eb69fe4f97024d073b3
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

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