4-Methylpyrazole → [4-(2-Fluoro-4-trifluoromethyl-phenyl)-piperazin-1-yl]-[5-methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-phenyl]-methanone

HRID 736241Notes

Reaction equation

HRID 736241 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][N:15]([C:18]([C:20]2[CH:25]=[C:24]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:23]=[CH:22][C:21]=2I)=[O:19])[CH2:14][CH2:13]1.[CH3:31][C:32]1[CH:33]=[N:34][NH:35][CH:36]=1>>[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][N:15]([C:18]([C:20]2[CH:25]=[C:24]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:23]=[CH:22][C:21]=2[N:34]2[CH:33]=[C:32]([CH3:31])[CH:36]=[N:35]2)=[O:19])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 34064-MethylpyrazoleHCID 59793591[4-(2-Fluoro-4-trifluoromethyl-phenyl)piperazin-1-yl]-(2-iodo-5-methanesulfonyl-phenyl)-methanone

Product 1

HCID 68844178[4-(2-Fluoro-4-trifluoromethyl-phenyl)-piperazin-1-yl]-[5-methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-phenyl]-methanoneYield 30%

Procedure

The title compound was prepared according to the procedure described for example 294 from [4-(2-Fluoro-4-trifluoromethyl-phenyl)-piperazin-1-yl]-(2-iodo-5-methanesulfonyl-phenyl)-methanone (compound CN) and 4-Methyl-1H-pyrazole (30% yield, light brown solid, MS (m/e): 511.2 (M+H, 100%)

Sources & evidence

ORD record
ord-983c0e8dbc814acd804c98fbb68c51a9
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

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