4-Methylpyrazole → [4-(2-Fluoro-4-trifluoromethyl-phenyl)-piperazin-1-yl]-[5-methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-phenyl]-methanone

Participants

Role	Name	HCID	Charge
Reactant	4-Methylpyrazole	HCID 3406	—
Reactant	[4-(2-Fluoro-4-trifluoromethyl-phenyl)piperazin-1-yl]-(2-iodo-5-methanesulfonyl-phenyl)-methanone	HCID 59793591	—
Product	[4-(2-Fluoro-4-trifluoromethyl-phenyl)-piperazin-1-yl]-[5-methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-phenyl]-methanone	HCID 68844178	30%

Reaction Steps

The title compound was prepared according to the procedure described for example 294 from [4-(2-Fluoro-4-trifluoromethyl-phenyl)-piperazin-1-yl]-(2-iodo-5-methanesulfonyl-phenyl)-methanone (compound CN) and 4-Methyl-1H-pyrazole (30% yield, light brown solid, MS (m/e): 511.2 (M+H, 100%)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07595314B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-983c0e8dbc814acd804c98fbb68c51a9
Source note	uspto-grants-2009_09