反应详情

To a mixture of 3,5,6,7,8,8a-hexahydro-1H-isochromene (0.410 g, 2.97 mmol) in CH2Cl2 (10 mL) at 0° C. was added MCPBA (˜77%, 1.24 g, 445 mmol). The mixture was stirred at rt for 3 hr. It was quenched with sated aq. sodium sulfite. The mixture was diluted with CH2Cl2 and sat'd. aq. NaHCO3 then extracted 3× with CH2Cl2. The combined organics were dried (anhd. Na2SO4), filtered, and concentrated. The residue was purified by column chromatography to give the title compound.

1. customIt was quenched with sated aq. sodium sulfite
2. additionThe mixture was diluted with CH2Cl2
3. extractionaq. NaHCO3 then extracted 3× with CH2Cl2
4. dry with materialThe combined organics were dried (anhd. Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated
7. customThe residue was purified by column chromatography