HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one | HCID 567033 | — |
| Reactant | HCID 178426711 | HCID 178426711 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pyrimidine | HCID 10686149 | 46.5% |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one (25 g, 0.14 mol), 2-methyl-5-nitrophenyl-guanidine nitrate (36 g, 0.14 mol), and sodium hydroxide (6.5 g, 0.163 mol) were dissolved in isopropanol and reacted under reflux for 18 hours. The reaction solution was cooled to 0° C., filtered, washed with isopropanol and methanol, and dried to give N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine (20 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595323B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-b0d47b7ff88d49628c5e10429a5628ae |
| Source note | uspto-grants-2009_09 |