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HRID736294

反应详情

EQUATION

反应方程式

HRID 736294 的结构方程式

REACTANTS

反应物

3
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CN(C)C=CC(=O)c1cccnc1
HCID567033

3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one

C10H12N2O

结构：Cc1ccc([N+](=O)[O-])cc1NC(=N)N.O=[N+]([O-])O
HCID178426711

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc([N+](=O)[O-])cc1Nc1nccc(-c2cccnc2)n1
HCID10686149

N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine

C16H13N5O2

收率 46.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one (25 g, 0.14 mol), 2-methyl-5-nitrophenyl-guanidine nitrate (36 g, 0.14 mol), and sodium hydroxide (6.5 g, 0.163 mol) were dissolved in isopropanol and reacted under reflux for 18 hours. The reaction solution was cooled to 0° C., filtered, washed with isopropanol and methanol, and dried to give N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine (20 g).

WORKUP

后处理

  1. customreacted
  2. temperatureunder reflux for 18 hours
  3. filtrationfiltered
  4. washwashed with isopropanol and methanol
  5. customdried