Methanesulfonic Acid → 4-(4-methylhomopiperazin-1-ylmethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-yl) aminophenyl]benzamide methanesulfonate

HRID 736297Notes

Reaction equation

HRID 736297 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([CH2:9][C:10]2[CH:38]=[CH:37][C:13]([C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[C:19]([NH:24][C:25]4[N:30]=[C:29]([C:31]5[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=5)[CH:28]=[CH:27][N:26]=4)[CH:18]=3)=[O:15])=[CH:12][CH:11]=2)[CH2:4][CH2:3]1.[CH3:39][S:40]([OH:43])(=[O:42])=[O:41]>C(O)C>[CH3:39][S:40]([OH:43])(=[O:42])=[O:41].[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[C:19]([NH:24][C:25]4[N:30]=[C:29]([C:31]5[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=5)[CH:28]=[CH:27][N:26]=4)[CH:18]=3)=[O:15])=[CH:37][CH:38]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 112721394-(4-methylhomopiperazin-1-ylmethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide

Product 1

HCID 865953394-(4-methylhomopiperazin-1-ylmethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-yl) aminophenyl]benzamide methanesulfonateYield 88.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-(4-Methylhomopiperazin-1-ylmethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide (250 mg, 0.429 mmol) was dissolved in ethanol (10 ml), methanesulfonic acid (64 μl, 0.984 mmol) was added, and the mixture was reacted at room temperature for 16 hours. The resulting solid was filtered and washed with acetone to give 4-(4-methylhomopiperazin-1-ylmethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide methanesulfonate (230 mg).

Workup

  1. customthe mixture was reacted at room temperature for 16 hours
  2. filtrationThe resulting solid was filtered
  3. washwashed with acetone

Sources & evidence

ORD record
ord-e4d61f0872244009aef1f9e60116b06e
Source dataset
uspto-grants-2009_09
Patent number
US07595323B2

Reaction notes

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