Methanesulfonic Acid → 4-(4-methylpiperazin-N-ylaminomethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide methanesulfonate
Reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([NH:8][CH2:9][C:10]2[CH:38]=[CH:37][C:13]([C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[C:19]([NH:24][C:25]4[N:30]=[C:29]([C:31]5[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=5)[CH:28]=[CH:27][N:26]=4)[CH:18]=3)=[O:15])=[CH:12][CH:11]=2)[CH2:4][CH2:3]1.[CH3:39][S:40]([OH:43])(=[O:42])=[O:41]>C(O)C>[CH3:39][S:40]([OH:43])(=[O:42])=[O:41].[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([NH:8][CH2:9][C:10]2[CH:38]=[CH:37][C:13]([C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[C:19]([NH:24][C:25]4[N:30]=[C:29]([C:31]5[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=5)[CH:28]=[CH:27][N:26]=4)[CH:18]=3)=[O:15])=[CH:12][CH:11]=2)[CH2:4][CH2:3]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4-(4-Methylpiperazin-1-ylaminomethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide (95 mg, 0.187 mmol) was dissolved in ethanol (8 ml), methanesulfonic acid (24 μl, 0.347 mmol) was added thereto, and the mixture was reacted at room temperature for 16 hours. The resulting solid was filtered and washed with acetone to give 4-(4-methylpiperazin-N-ylaminomethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide methanesulfonate (80 mg).
Workup
- customthe mixture was reacted at room temperature for 16 hours
- filtrationThe resulting solid was filtered
- washwashed with acetone
Sources & evidence
- ORD record
- ord-9427bd5b76ad4c588b5d29eb1c252ac1
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07595323B2
Reaction notes
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