HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → N-(4-methyl-3-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one | HCID 567033 | — |
| Reactant | HCID 178426527 | HCID 178426527 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N-(4-methyl-3-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine | HCID 68816439 | 104,130,488% |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one (20 g, 0.1 μmol), 4-methyl-3-nitrophenyl-guanidine nitrate (32 g, 0.12 mol), and sodium hydroxide (6.8 g, 0.17 mol) were dissolved in isopropanol, and reacted under reflux for 28 hours. The reaction solution was cooled to 0° C., filtered, washed with isopropanol, water and ethanol, and dried to give N-(4-methyl-3-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine (32 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595323B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-c889cb5cf0f146dbb3fcec9eacea389b |
| Source note | uspto-grants-2009_09 |