反应详情

4-(4-Methylhomopiperazin-1-ylmethyl)-N-[2-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide (1.2 g, 2.29 mmol) was dissolved in ethanol (18 ml), methanesulfonic acid (149 μl, 2.29 mmol) was added, and the mixture was reacted at room temperature for 18 hours. The resulting solid was filtered and washed with acetone to give 4-(4-methylhomopiperazin-1-ylmethyl)-N-[2-methyl-5-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide methanesulfonate (1.03 g).

1. customthe mixture was reacted at room temperature for 18 hours
2. filtrationThe resulting solid was filtered
3. washwashed with acetone