反应详情

1-Methylpiperazine (0.58 g, 5.77 mmol) and N-[4-fluoro-3-(4-chloromethylbenzoyl amino)-phenyl]-4-(3-pyridyl)-2-pyrimidine-amine (1 g, 2.31 mmol) were reacted according to the same procedure as Example 1 to give 4-(4-methylpiperazin-1-ylmethyl)-N-[2-fluoro-5-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide (1.1 g).