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6-Bromo-N-methoxy-N-methylpicolinamide → (6-Bromo-pyridin-2-yl)-(4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Bromo-N-methoxy-N-methylpicolinamide | HCID 24730332 | — |
| 反応物 | 5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine | HCID 45789428 | — |
| 反応物 | (5-Bromo-pyridin-3-yl)-(4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone | HCID 86603152 | — |
| 生成物 | (6-Bromo-pyridin-2-yl)-(4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone | HCID 86603155 | 69% |
反応手順
The title compound (34.0 g, 69%) was prepared from 5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine (35.8 g, 130.5 mmol) and 6-Bromo-pyridine-2-carboxylic acid methoxy-methyl-amide (32.0 g, 130.5 mmol) by procedures analogous to those described for the preparation (5-Bromo-pyridin-3-yl)-(4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone. MS: 380.6 (MH+); HPLC Rf: 6.05 min. (HPLC method 4); HPLC purity: 100%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07595325B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-8eda0b4f3ae143f884c7a41f07949abb |
| 出典メモ | uspto-grants-2009_09 |