HCID 68903795, compound → (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(6-amino-pyridin-2-yl)-methanone

HRID 736342Notes

Reaction equation

HRID 736342 reaction equation
BrC1N=C(C(C2C3C(Cl)=NC=[N:14][C:13]=3[N:12](C(C)C)C=2)=O)C=CC=1.[NH2:23][C:24]1[C:25]2[C:32]([C:33]([C:35]3C=N[CH:38]=[C:39](N)[CH:40]=3)=[O:34])=[CH:31][N:30]([CH:42]([CH3:44])[CH3:43])[C:26]=2[N:27]=[CH:28][N:29]=1>>[NH2:23][C:24]1[C:25]2[C:32]([C:33]([C:35]3[CH:40]=[CH:39][CH:38]=[C:13]([NH2:14])[N:12]=3)=[O:34])=[CH:31][N:30]([CH:42]([CH3:43])[CH3:44])[C:26]=2[N:27]=[CH:28][N:29]=1

Participants

3

Reactant 2

HCID 68903795HCID 68903795, compoundHCID 86603155(6-Bromo-pyridin-2-yl)-(4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone

Product 1

HCID 68908256(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(6-amino-pyridin-2-yl)-methanoneYield 85%

Procedure

The title compound (5.30 g, 85%) was prepared from (6-Bromo-pyridin-2-yl)-(4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone (8.0 g, 21.3 mmol) by procedures analogous to those described for the preparation of (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(5-amino-pyridin-3-yl)-methanone. MS: 297.1 (MH+); HPLC Rf: 370 min. (HPLC method 4); HPLC purity: 100%.

Sources & evidence

ORD record
ord-302926800f4b40f6908c0d38e0c39af4
Source dataset
uspto-grants-2009_09
Patent number
US07595325B2

Reaction notes

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