돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 736347생성일: 2026년 10월 25일

2-Chloro-N-methoxy-N-methylisonicotinamide → (4-Chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(2-chloro-pyridin-4-yl)-methanone

https://huagongshe.com/reaction/736347

반응식

참여 물질

역할이름HCID투입량
반응물2-Chloro-N-methoxy-N-methylisonicotinamideHCID 18506894—
반응물5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidineHCID 45789428—
반응물(5-Bromo-pyridin-3-yl)-(4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanoneHCID 86603152—
생성물(4-Chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(2-chloro-pyridin-4-yl)-methanoneHCID 86603156—

반응 단계

The title compound was prepared from 5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine (6.5 g, 23.7 mmol) and 2-Chloro-N-methoxy-N-methyl-isonicotinamide (5.7 g, 28.4 mmol) by procedures analogous to those described for the preparation of (5-Bromo-pyridin-3-yl)-(4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone. MS: 295.8 (MH−); HPLC Rf: 2.0 min. (HPLC method 2); HPLC purity: 100%.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07595325B2
출처 데이터셋uspto-grants-2009_09
ORD IDord-b843ce9c8a3f46a791aa515924f1c84d
출처 메모uspto-grants-2009_09