5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine → (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(4-amino-pyridin-2-yl)-methanone

HRID 736350Notes

Reaction equation

HRID 736350 reaction equation
BrC1C2C(Cl)=NC=NC=2[N:4](C(C)C)C=1.CON(C)C(C1C=C(Cl)C=CN=1)=O.[NH2:28][C:29]1[C:30]2[C:37]([C:38]([C:40]3[CH:45]=[CH:44][CH:43]=[C:42](N)[N:41]=3)=[O:39])=[CH:36][N:35]([CH:47]([CH3:49])[CH3:48])[C:31]=2[N:32]=[CH:33][N:34]=1>>[NH2:28][C:29]1[C:30]2[C:37]([C:38]([C:40]3[CH:45]=[C:44]([NH2:4])[CH:43]=[CH:42][N:41]=3)=[O:39])=[CH:36][N:35]([CH:47]([CH3:49])[CH3:48])[C:31]=2[N:32]=[CH:33][N:34]=1

Participants

4

Reactant 3

HCID 457894285-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidineHCID 535108144-chloro-N-methoxy-N-methylpyridine-2-carboxamideHCID 68908256(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(6-amino-pyridin-2-yl)-methanone

Product 1

HCID 68908281(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(4-amino-pyridin-2-yl)-methanone

Procedure

The title compound was prepared from 5-Bromo4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine (6.5 g, 23.7 mmol) and 4-Chloro-pyridine-2-carboxylic acid methoxy-methyl-amide (5.7 g, 28.5 mmol) by procedures analogous to those described for the preparation (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(6-amino-pyridin-2-yl)-methanone. MS:

Sources & evidence

ORD record
ord-a687c45950a946eca8050efd7411b048
Source dataset
uspto-grants-2009_09
Patent number
US07595325B2

Reaction notes

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