5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine → (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(4-amino-pyridin-2-yl)-methanone

Participants

Role	Name	HCID	Charge
Reactant	5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine	HCID 45789428	—
Reactant	4-chloro-N-methoxy-N-methylpyridine-2-carboxamide	HCID 53510814	—
Reactant	(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(6-amino-pyridin-2-yl)-methanone	HCID 68908256	—
Product	(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(4-amino-pyridin-2-yl)-methanone	HCID 68908281	—

Reaction Steps

The title compound was prepared from 5-Bromo4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine (6.5 g, 23.7 mmol) and 4-Chloro-pyridine-2-carboxylic acid methoxy-methyl-amide (5.7 g, 28.5 mmol) by procedures analogous to those described for the preparation (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(6-amino-pyridin-2-yl)-methanone. MS:

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07595325B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-a687c45950a946eca8050efd7411b048
Source note	uspto-grants-2009_09