Dichloromethane → HCID 68584049, compound

HRID 736426Notes

Reaction equation

HRID 736426 reaction equation
[CH:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][N:20]([C:23]3([C:29]([O:31]C(C)(C)C)=[O:30])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[CH2:19][CH2:18]2)=[O:14])[C:5]1=[O:36])([CH3:3])[CH3:2].FC(F)(F)C(O)=O.[Cl:44]CCl>>[ClH:44].[CH:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([C:13]([NH:15][CH2:16][CH:17]2[CH2:18][CH2:19][N:20]([C:23]3([C:29]([OH:31])=[O:30])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[CH2:21][CH2:22]2)=[O:14])[C:5]1=[O:36])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 68585066HCID 68585066, compound

Product 1

HCID 68584049HCID 68584049, compound

Procedure

To a stirred solution of tert-butyl 1-[4-({[(3-isopropyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)carbonyl]amino}methyl)piperidin-1-yl]cyclohexanecarboxylate (400 mg, 0.802 mmol) in dichloromethane (5 mL) was added trifluoroacetic acid (5 mL, 65.2 mmol) at room temperature. After 12 h, the volatile components were removed under reduced pressure. To the residue was added 4N HCl in dioxane (5.0 mL) was added and stirred for 10 min. Then, the volatile was removed under reduced pressure.

Workup

  1. customthe volatile components were removed under reduced pressure
  2. additionTo the residue was added 4N HCl in dioxane (5.0 mL)
  3. additionwas added
  4. customThen, the volatile was removed under reduced pressure

Sources & evidence

ORD record
ord-6cd5addbf4e94774b00fb1ef910560f4
Source dataset
uspto-grants-2009_09
Patent number
US07595329B2

Reaction notes

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