Hydrogen Peroxide → HCID 11976494, compound

HRID 736448Notes

Reaction equation

HRID 736448 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]([CH3:13])([CH3:12])[C:10]#[N:11].[OH-:14].[Na+].OO>>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]([CH3:13])([CH3:12])[C:10]([NH2:11])=[O:14]

Participants

4

Reactant 3

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 11976442HCID 11976442, compound

Product 1

HCID 11976494HCID 11976494, compound

Procedure

Hydrolysis of 2-(2,3-difluorophenyl)-2-methylpropionitrile was performed according to the procedure of Example 10 using sodium hydroxide in the presence of hydrogen peroxide to provide 2-(2,3-difluorophenyl)isobutyramide [1H-NMR (CDCl3): δ 7.17-7.08 (m, 3H), 5.98 (br s, 1H), 5.45 (br s, 1H), 1.60 (s, 6H)].

Sources & evidence

ORD record
ord-437635596d0544c1814bc456fb85e614
Source dataset
uspto-grants-2009_09
Patent number
US07595338B2

Reaction notes

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