Hydrogen Peroxide → HCID 11976495, compound

HRID 736449Notes

Reaction equation

HRID 736449 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]([CH3:13])([CH3:12])[C:10]#[N:11].[OH-:14].[Na+].OO>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]([CH3:13])([CH3:12])[C:10]([NH2:11])=[O:14]

Participants

4

Reactant 3

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 11976493HCID 11976493, compound

Product 1

HCID 11976495HCID 11976495, compound

Procedure

Hydrolysis of 2-(2,6-difluorophenyl)-2-methylpropionitrile was performed according to the procedure of Example 10 using sodium hydroxide in the presence of hydrogen peroxide to provide 2-(2,6-difluorophenyl)isobutyramide [1H-NMR (CDCl3): δ 7.34-7.29 (m, 1H), 6.91-6.85 (m, 2H), 6.43 (br s, 1H), 5.73 (br s, 1H), 1.68-1.66 (m, 6H)].

Sources & evidence

ORD record
ord-5637eccfbda84d49a0d1cfa3abb14fb3
Source dataset
uspto-grants-2009_09
Patent number
US07595338B2

Reaction notes

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