反应详情

温度

170 °C

Methyl-3-amino-2-thiophene carboxylate (510 mg, 3.24 mmol) was dissolved in formamide (20 ml) and heated at 170° C. 16 h. The solvent was evaporated. The crude residue was then purified by flash chromatography on silica gel (2-4% MeOH/CH2Cl2) to afford the title compound 256 (157 mg, 32% yield). LRMS: 152.0 (Calc.); 152.9 (found).

1. custom16 h
2. customThe solvent was evaporated
3. customThe crude residue was then purified by flash chromatography on silica gel (2-4% MeOH/CH2Cl2)