反应详情

温度

60 °C

To an ambient temperature solution of 4-{1-Ethyl-1-[4-(1-hydroxy-cyclopentylethynyl)-3-methyl-phenyl]-propyl}-2-methyl-benzoic acid methyl ester (2.40 g, 5.73 mmol) in dioxane/water (30/30 ml) is added lithium hydroxide (412 mg, 17.20 mmol) and heated to 60° C. for 1 h. The reaction is concentrated and partitioned between Et2O/EtOAc (150/150 ml) and 1N HCl (50 ml). The aqueous phase is extracted with a second portion of EtOAc (100 ml) and the combined organic phases are washed with water (50 ml), brine (50 ml), dried (MgSO4) and concentrated to yield the title compound (1.57 g, 68%).

1. concentrationThe reaction is concentrated
2. custompartitioned between Et2O/EtOAc (150/150 ml) and 1N HCl (50 ml)
3. extractionThe aqueous phase is extracted with a second portion of EtOAc (100 ml)
4. washthe combined organic phases are washed with water (50 ml), brine (50 ml)
5. dry with materialdried (MgSO4)
6. concentrationconcentrated