p-Bromobenzenesulfonyl chloride → HCID 669771, compound

HRID 736610Notes

Reaction equation

[CH2:1]([NH2:6])[CH2:2][CH:3]([CH3:5])[CH3:4].[Br:7][C:8]1[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[CH:10][CH:9]=1>>[Br:7][C:8]1[CH:13]=[CH:12][C:11]([S:14]([NH:6][CH2:1][CH2:2][CH:3]([CH3:5])[CH3:4])(=[O:16])=[O:15])=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 7396p-Bromobenzenesulfonyl chloride

HCID 7894Isoamylamine

Product 1

HCID 669771HCID 669771, compoundYield 98%

Procedure

Starting materials: isoamylamine and 4-bromobenzenesulfonyl chloride. Yield 98% as a white solid: 1H NMR (CDCl3) δ 7.71 (d, J=9 Hz, 2H), 7.62 (d, J=9 Hz, 2H), 4.26 (br s, 1H), 2.82 (t, J=7 Hz, 2H), 1.52 (m, 1H), 1.30 (q, J=7 Hz, 2H), 0.86 (s, 3H), 0.84 (s, 3H); 13C NMR (CDCl3) δ 139.3, 132.6, 128.8, 127.7, 41.7, 38.6, 25.6, 22.8, 22.4; MS (ESP) m/z 306, 308 (M++1).

Sources & evidence

ORD record: ord-a647ef9cdc784cd2bc2f0dc0dc2d89a7
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595319B2

Reaction notes

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