3-Pyridinecarboxaldehyde → HCID 10218753, compound

HRID 736684Notes

Reaction equation

FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.[CH3:22][C:23]1[CH:32]=[C:31]([CH2:33][O:34][C:35]2[CH:59]=[CH:58][C:38]([C:39]([NH:41][CH2:42][C:43]3([N:52]4[CH2:57][CH2:56][NH:55][CH2:54][CH2:53]4)[C:48](=[O:49])[NH:47][C:46](=[O:50])[NH:45][C:44]3=[O:51])=[O:40])=[CH:37][CH:36]=2)[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[N:24]=1.[N:60]1[CH:65]=[CH:64][CH:63]=[C:62]([CH:66]=O)[CH:61]=1>>[CH3:22][C:23]1[CH:32]=[C:31]([CH2:33][O:34][C:35]2[CH:36]=[CH:37][C:38]([C:39]([NH:41][CH2:42][C:43]3([N:52]4[CH2:53][CH2:54][N:55]([CH2:66][C:62]5[CH:61]=[N:60][CH:65]=[CH:64][CH:63]=5)[CH2:56][CH2:57]4)[C:44](=[O:51])[NH:45][C:46](=[O:50])[NH:47][C:48]3=[O:49])=[O:40])=[CH:58][CH:59]=2)[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[N:24]=1

Participants

Reactant 2

HCID 103713-Pyridinecarboxaldehyde

HCID 86590474HCID 86590474, compound

Product 1

HCID 10218753HCID 10218753, compoundYield 51%

Procedure

Following the procedure analogous to that used in reaction (9), the compound from Example 8 was reacted with 3-pyridine-carboxaldehyde for 2 days to provide the title compound (7.6 mg, 51%). MS found: (M+H)+=608.4.

Sources & evidence

ORD record: ord-82716d7055fd43dea4cad8423a97a227
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595317B2

Reaction notes

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