反应详情

To a mixture of 2,3-diaminobenzamide dihydrochloride (synthesized as described in U.S. Pat. No. 6,737,421, column 11, EXAMPLE 2, step (e), 5 g, 22.3 mmol) and 4-bromobenzaldehyde (4.13 g, 22.3 mmol) in methanol (200 mL) was added 10% Pd/C (1.3 g). The mixture was refluxed overnight, then cooled and filtered though a pad of celite. The filtrate was concentrated under vacuum and purified by chromatography on a silica gel column with 0-10% methanol/dichloromethane to provide the title compound (1.2 g, 17%). MS (ESI) m/e 317 (M+H)+.

1. customsynthesized
2. temperatureThe mixture was refluxed overnight
3. temperaturecooled
4. filtrationfiltered though a pad of celite
5. concentrationThe filtrate was concentrated under vacuum
6. custompurified by chromatography on a silica gel column with 0-10% methanol/dichloromethane