Hydroxylamine → HCID 86607867, compound

HRID 736711Notes

Reaction equation

HRID 736711 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10]([CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([S:20]([NH:23][C@H:24]3[CH2:29][CH2:28][CH2:27][CH2:26][C@H:25]3[C:30](O)=[O:31])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:33][OH:34]>>[OH:34][NH:33][C:30]([C@@H:25]1[CH2:26][CH2:27][CH2:28][CH2:29][C@@H:24]1[NH:23][S:20]([C:17]1[CH:16]=[CH:15][C:14]([O:13][CH2:12][C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=[C:2]([CH3:1])[CH:11]=2)=[CH:19][CH:18]=1)(=[O:22])=[O:21])=[O:31]

Participants

3

Reactant 2

HCID 787HydroxylamineHCID 68821094cis-2-[({4-[(2-Methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxylic acid

Product 1

HCID 86607867HCID 86607867, compoundYield 46%

Procedure

According to the procedure of Example 10, Step 2, the reaction of 113.6 mg (0.5 mmol) of cis-2-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxylic acid with hydroxylamine provided 53.7 mg of the title compound in 46% yield. MS: 470.1 (M+H)+

Sources & evidence

ORD record
ord-b978ecfa6fb543d7a128ee1d43787e62
Source dataset
uspto-grants-2009_09
Patent number
US07595327B2

Reaction notes

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