HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxylamine → trans-N-hydroxy-2-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | trans-2-[({4-[(2-Methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxylic acid | HCID 68819595 | — |
| Product | trans-N-hydroxy-2-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxamide | HCID 86607868 | 16% |
Reaction Steps
According to the procedure of Example 10, Step 2, the reaction of 186.8 mg (0.4 mmol) of trans-2-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxylic acid with hydroxylamine provided 31.8 mg of trans-N-hydroxy-2-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxamide in 16% yield. MS: 470.1 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595327B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-39ad39b931c44e6794e0a57204bf834d |
| Source note | uspto-grants-2009_09 |